Before You Go Shopping For CoQ10 Read This.
So what Is CoQ10 and what does it do?
Coenzyme Q (CoQ10) is an essential step in bioenergetics in the electron transport chain and in the antioxidant protection of cell membranes. As the main antioxidant in blood, coenzyme Q prevents the oxidation of lipoproteins (1). CoQ10 is the mobile component of the mitochondria electron transport chain. CoQ10 plays an essential role in the energy production of our cells. CoQ10 is used in the electron transport chain to produce adenosine triphosphate (ATP). This ATP is used up to produce cellular energy. So if there is no usable CoQ10 the production of ATP slows, then you have less energy. Although our body does produce this naturally sometimes with mitochondrial dysfunction or aging, supplementation can help.
How Does CoQ10 Work In The Body
The main function of CoQ10 in the body is the production of cellular energy or adenosine triphosphate (ATP). It is the most critical component in all mitochondria which are present in practically every cell in our body totaling from 600- 2000 mitochondria per cell (2). CoQ10 is used up in the first proton pump (complex 1) of the electron transport chain. CoQ10 is a crucial component within the electron transport chain (respiratory chain) in the mitochondria where energy is derived by a process called oxidative phosphorylation from the fuel products of fatty acid and where acetyl-l-carnitine acts like a shuttle, as well as protein and carbohydrate metabolism. These basic fuels are converted into biological energy called adenosine triphosphate (3). Also CoQ10 is a potent antioxidant and it helps protect tissues and cellular components in the body called reactive oxygen species (ROS). Unfortunately while producing ATP the cells produce excess free radicals, thats where CoQ10 comes in and wipes them out. If you are lacking available antioxidants like CoQ10 the body can produce dna damage, tissue damage or inflammation to name a few.
How Can CoQ10 benefit you…
- Protections against free radicals
- ATP production (energy)
- Reduce Heart Failure (4)
- For women it has shown to help fertility (5)
- Reducing the symptoms from statin drugs (6)
Where can you find CoQ10
- organ meats, such as kidney and liver
- fatty fish, such as sardine and trout
- whole grains
CoQ10 Supplements, yours may be inferior
So did you know that your CoQ10 supplement may not be even working? There are a few forms of CoQ10 and they are all different.
Lets take a look at the least bioavailable form ubiquinone. ubiquinone is the “oxidized” form of CoQ10 (source). The term reduced refers to the loss of negatively charged particles known as electrons, respectively. Studies show that ubiquinone is less bioavailable in the body serum levels. That means if you are taking the ubiquinone form of CoQ10 in your blood there is less of the actually available form of Coq10 that your cells can use. This form must be metabolized by the cells making them less effective.
Ubiquinol is much superior to ubiquinone. Studies show that in just two weeks ubiquinol increased plasma ubiquinone levels 1.7 fold (7). The reason ubiquinol is more bio-available is the fact that it is reduced. The reduction means that the CoQ10 gains an electron to the ubiquinol making it easier for the cell to accept and utilize. ubiquinol that is the antioxidant or protective form of CoQ10. This is because its reduced state allows it to neutralize free radicals and thereby prevent them from damaging cellular DNA, lipids, and proteins. Therefore CoQ10 supplements that contain ubiquinone must first be metabolized into ubiquinol in the body in order to exert their antioxidant effects. So this form is fantastic at getting into the cells and can be used more effectively than ubiquinone.
Next let’s look at the newer version called MitoQ. MitoQ was produced in New Zealand and its company has touted its clinical effectiveness over other forms of CoQ10. The reason the claim it is more effective is because they have a patented form of Mitoquinol. Mitoquinol is CoQ10 bound to a positively charged ion (cation). It is true that mitochondria can accept a positively charged element through its membranes more effectively. There is over 400 peer-reviewed papers on this method of action.
MitoQ takes a shortened version of CoQ10 and gives it a positive charge. The result of these modifications is what makes MitoQ a scientific breakthrough:
- MitoQ is instantly attracted to the negatively charged mitochondria; and
- MitoQ is able to pass directly through the mitochondrial membrane.
These unique properties mean that MitoQ is absorbed directly into your mitochondria hundreds of times more effectively than standard CoQ10 supplements. (mitoq.com)
So Which Supplement Should I Take?
Well for starters think about how much you can afford. MitoQ is the most costly and ubiquinone is the least expensive. I personally take ubiquinol and Mitoq at times. However, my main course is ubiquinol and im taking about 600mg a day to make sure my plasma levels are high. I do notice that Mitoq does give me a boost of energy in just an hour after taking it.
I suggest speaking with your doctor on what dosage is correct for you. I would say the label recommendation is a good start. If you are looking for a way to boost your cells and do it on the cheap then ubiquinol is the way to go hands down. To see what I’m taking or what I suggest check out the links below.
My current supplements or the ones I suggest buying because the manufactures have a higher quality of manufacturing and no additives.
Ubiquional (all of these are great and can be found on Amazon)
Also the MitoQ Brand is also listed Below
1. Fuillermo Lopez. Physiological Aspects of COQ10 Retrieved 2/21/20 from https://www.sciencedirect.com/topics/medicine-and-dentistry/ubiquinone
2. Ernster L, Dallner G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271(1): 195-204
3. Fossilien E (2001) Mitochondrial medicine-molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci 31(1): 25‐76.
4. Qu H (2018) Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials. Retrieved 2/2/20 from https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009835
5. Bhutani J (2015) Coenzyme Q10 for the treatment of heart failure: a review of the literature. Retrieved 2/20/20 from https://www.ncbi.nlm.nih.gov/pubmed/26512330
6. Meir A (2015) Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Retrieved 2/20/20 https://www.ncbi.nlm.nih.gov/pubmed/26111777
(7) Oliver C (2019) Bioavailable source of Ubiquinol and Ubiquinone in older adults. Retrieved 2/20/20 from https://clinicaltrials.gov/ct2/show/NCT03020680